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For individuals with symptomatic illness requiring therapy, ibrutinib is frequently recommended based on 4 stage III randomized medical trials comparing ibrutinib with chlorambucil monotherapy106 as well as other generally made use of CIT combinations, namely FCR, bendamustine additionally rituximab and chlorambucil furthermore obinutuzumab (ClbO).107–109 Ibrutinib was superior to chlorambucil and all CIT combos in terms of response charge and development-free survival, and also conferred a longer General survival as compared to that provided by chlorambucil monotherapy and FCR.

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